姓 名：唐存多
性 别：男
职 称：副教授
电子邮箱：tcd530@126.com
人才称号：河南省高校科技创新人才，河南省青年科学家，河南省青年人才托举工程人选
一、学习经历
2008.09-2014.01，江南大学，发酵工程，博士
2004.09-2008.06，苏州科技大学，生物技术，学士
二、工作经历
2024.05-，南阳师范学院生命科学学院，副教授
2020.10-2024.04，南阳师范学院生命科学与农业工程学院，副教授
2015.09-2020.09，南阳师范学院农业工程学院，讲师、副教授
2014.02-2015.08，南阳师范学院生命科学与技术学院，讲师
三、教学工作
主讲课程
本科生：《基因工程》《蛋白质技术》《酶工程》《蛋白质组学》《发酵工艺学》等课程的教学工作。
四、科学研究方向
人工智能辅助蛋白质的理性设计与改造、功能性食品及药物中间体的生物合成、二氧化碳的人工捕获封存与高值利用。
五、科研成果
（一）科研项目
1. 国家自然科学基金委员会，青年项目，31900916，D-扁桃酸脱氢酶底物选择性的分子机制及其理性改造，2020-01至2022-12，25万元，已结题，主持。
2. 河南省教育厅，河南省高校科技创新人才，21HASTIT041，生物催化与生物合成，2021-01至2023-12，30万元，已结题，主持。
3. 河南省科学技术协会，河南省青年人才托举工程项目，2021HYTP036，高产γ-氨基丁酸微生物细胞工厂的设计与构建，2021-01至2022-12，已结题，主持。
4. 河南省科技厅，河南省青年科学家项目，225200810076，基于计算机辅助的底物口袋工程对甲酸脱氢酶催化活性的分子改造，2023-01至2024-12，在研，主持。
（二）论文著作
1. Shi Hongling, Fu Muran, Yuan Shuwei, Lu Yunfeng, Yang Zhuan, Yue Chao, Yao Lunguang*, Xue Chuang*, Tang Cunduo*. Engineered Escherichia coli Whole Cell-Mediated Electro-Biocatalysis for Carbon Dioxide to Formic Acid Conversion. ACS Sustainable Chem. Eng. 2024, 12 (14): 5544-5554. (中科院JCR1区)
2. Hu Die, Jia Xue-Wei, Lu Jia-Lan, Lu Zhi-Yi, Tang Cunduo*, Xue Feng, Huang Chao, Ren Qing-Gong, He Yu-Cai*. Chemoenzymatic Asymmetric Synthesis of Chiral Triazole Fungicide (R)-Tebuconazole in High Optical Purity Mediated by an Epoxide Hydrolase from Rhodotorula paludigensis. J Agric Food Chem 2024, 72 (18): 10428-10438. (中科院JCR1区)
3. Zhang Xiang, Zhang Xichuan, Shi Hongling, Zhang Huimin, Zhang Jianhui, Yue Chao, Li Dandan*, Yao Lunguang*, Tang Cunduo*. Combining Flexible Region Design and Automatic Design to Enhance the Thermal Stability and Catalytic Efficiency of Leucine Dehydrogenase. J Agric Food Chem 2024, 72 (24): 13801-13811. (中科院JCR1区)
4. Tang Cunduo*, Li Xiang, Shi Hong-Ling, Jia Yuan-Yuan, Dong Zi-Xing, Jiao Zhu-Jin, Wang Lin-Feng, Xu Jian-He, Yao Lun-Guang*, Kan Yun-Chao*. Efficient expression of novel glutamate decarboxylases and high level production of gamma-aminobutyric acid catalyzed by engineered Escherichia coli. Int J Biol Macromol 2020, 160: 372-379. (中科院JCR1区)
5. Tang Cunduo*, Ding Peng-Ju, Shi Hong-Ling, Jia Yuan-Yuan, Zhou Mao-Zhi, Yu Hui-Lei, Xu Jian-He, Yao Lun-Guang*, Kan Yun-Chao*. One-Pot Synthesis of Phenylglyoxylic Acid from Racemic Mandelic Acids via Cascade Biocatalysis. J Agric Food Chem 2019, 67 (10): 2946-2953. (中科院JCR1区)
6. Tang Cun-Duo*, Shi Hong-Ling, Xu Jian-He, Jiao Zhu-Jin, Liu Feng, Ding Peng-Ju, Shi Hong-Fei, Yao Lun-Guang,Kan Yun-Chao. Biosynthesis of Phenylglyoxylic Acid by LhDMDH, a Novel D-Mandelate Dehydrogenase with High Catalytic Activity. J Agric Food Chem 2018, 66 (11): 2805-2811. (中科院JCR1区)
7. Liu Xin-Xin, Wang Yao, Zhang Jian-Hui, Lu Yun-Feng, Dong Zi-Xing, Yue Chao, Huang Xian-Qing, Zhang Si-Pu, Li Dan-Dan, Yao Lun-Guang, Tang Cun-Duo*. Engineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration. Biotechnology for Biofuels and Bioproducts 2024, 17 (1): 44. (中科院JCR2区)
8. Zhang Xiang, Zhang Xi-Chuan, Shi Hong-Ling, Zhang Hui-Min, Zhang Jian-Hui, Kan Yun-Chao, Li Dan-Dan, Yao Lun-Guang, Tang Cun-Duo*. Enhancing the thermostability of the leucine dehydrogenase from Planifilum fimeticola through rational design of the flexible region. Molecular Catalysis 2024, 559: 114048. (中科院JCR2区)
9. Liu Xin-Xin, Xi Xiao-Qi, Shen Tai-Song, Shi Hong-Ling, Zhang Ying-Jun, Kan Yun-Chao, Yao Lun-Guang, Tang Cun-Duo*. Enhancing biosynthesis efficiency of 2,5-dimethylpyrazine by overexpressing -threonine dehydrogenase and NADH oxidase in Escherichia coli. Molecular Catalysis 2023, 550: 113550. (中科院JCR2区)
10. Yuan Shu-Wei, Fu Mu-Ran, Xian Yi-Meng, Shi Hong-Ling, Chun Chang, Yao Lun-Guang, Tang Cun-Duo*, Chen Chang-Po. Efficient heterologous expression of formate dehydrogenase and preliminary determination of the potential for conversion of carbon dioxide to formate. Molecular Catalysis 2023, 548: 113455. (中科院JCR2区)
11. Tang Cun-Duo*, Zhang Xiang, Shi Hong-Ling, Liu Xin-Xin, Wang Hong-Yan, Lu Yun-Feng, Zhang Si-Pu, Kan Yun-Chao,Yao Lun-Guang. Improving catalytic activity of Lactobacillus harbinensis -mandelate dehydrogenase toward -o-chloromandelic acid by laboratory evolution. Molecular Catalysis 2022, 531: 112700. (中科院JCR2区)
12. Tang Cun-Duo, Zhang Zhen-Hua, Shi Hong-Ling, Xie Yu-Li, Yang Tian-Tian, Lu Yun-Feng, Zhang Si-Pu, Bai Fang-Hui, Kan Yun-Chao,Yao Lun-Guang. Directed evolution of formate dehydrogenase and its application in the biosynthesis of L-phenylglycine from phenylglyoxylic acid. Molecular Catalysis 2021, 513: 111666. (中科院JCR2区)
（三）授权专利
1. 唐存多，史红玲，阚云超，姚伦广，和子涵，焦铸锦，史鸿飞. 一种D-扁桃酸脱氢酶、基因、基因工程菌及其应用，2019-9-24，中国发明专利，ZL201710969932.0。
2. 唐存多，姚伦广，阚云超，史红玲，董自星，史鸿飞，焦铸锦. 一种编码谷氨酸脱羧酶LsGAD的基因、重组工程菌及康普茶发酵菌剂，2023-3-24，中国发明专利，ZL201911234346.7。
（四）科研及教学奖励
1. 唐存多(1/5); Biosynthesis of Phenylglyoxylic Acid by LhDMDH, a Novel D-Mandelate Dehydrogenase with High Catalytic Activity, 河南省教育厅, 河南省教育厅优秀学术论文奖,一等奖, 2021。
2. 唐存多(1/2); One-Pot Synthesis of Phenylglyoxylic Acid from Racemic Mandelic Acids via Cascade Biocatalysis, 河南省教育厅, 河南省教育厅优秀学术论文奖, 一等奖, 2022。
3. 唐存多(1/9); Biosynthesis of Phenylglyoxylic Acid by LhDMDH, a Novel D-Mandelate Dehydrogenase with High Catalytic Activity, 河南省人社厅/河南省科学技术协会, 河南省自然科学学术奖, 一等奖, 2021。