姓名：闫路
性别：女
学位：博士
专业：环境科学与工程
职称：讲师
所在院系：水资源与环境工程学院
一、个人简介
闫路，河南南阳人，博士，讲师。2014.09-2017.06在浙江工业大学资源环境学院环境科学专业学习，获得工学硕士学位；2017.09-2022.06在南京大学环境学院环境科学与工程专业学习，获得理学博士学位。2022.11至今在南阳师范学院工作。主讲《水资源保护与利用》、《环境毒理学》、《专业英语》。主要从事环境化学物质毒性测试与预测研究、基于组学测试的环境化学物质人体健康和生态健康效应评估，参与中瑞合作项目、江苏“外专百人计划”项目、江苏省重大技术攻关类项目各1项。
二、参与的项目
· 中瑞合作项目: Evaluation of dioxin effects on the fibrosis AOP in vitro
· 江苏“外专百人计划”: 基于CRISPR-Cas9功能基因组识别潜在致癌化学品表观遗传分子图谱
· 江苏省重大技术攻关: 江苏省环境与健康调查及风险评估体系建设研究
三、代表性论文
1. Yan L., Messner C. J., Zhang X., Suter-Dick L. Assessment of fibrotic pathways induced by environmental chemicals using 3D-human liver microtissue model [J]. Environmental Research, 2021, 194: 110679.
2. Yan L., Messner C. J., Tian M., Gou X., Zhang X., Suter-Dick L. Evaluation of dioxin induced transcriptomic responses in a 3D human liver microtissue model [J]. Environmental Research, 2022, 210: 112906.
3. 闫路，苟潇，彭颖，张效伟. 基于3D体外培养模型的化学物质肝毒性预测研究进展[J].生态毒理学报, 2021, 17(1): 299-312.
4. 闫路，苟潇，高瑞泽，吉慧敏，张效伟. 基于高通量组学方法的毒害污染物筛查与风险评估[J].科学通报, 2022, 67(35): 4159 ~ 4169.
5. Yan L., Zhang Q., Huang F., Nie W. W., Hu C. Q., Ying H. Z., Dong X. W., Zhao M. R. Ternary classification models for predicting hormonal activities of chemicals via nuclear receptors [J]. Chemical Physics Letters, 2018, 706: 360-6.
6. Yan L., Gong C., Zhang X., Zhang Q., Zhao M., Wang C. Perturbation of metabonome of embryo/larvae zebrafish after exposure to fipronil [J]. Environmental Toxicology and Pharmacology, 2016, 48: 39-45.
7. Bai X. X.#, Yan L.#, Zhang Q., Dong X. W., Zhao M. R. A combination of ternary classification models and reporter gene assays for the comprehensive thyroid hormone disruption profiles of 209 polychlorinated biphenyls [J]. Chemosphere, 2018, 210: 312-9.（共一）
8. Zhang Q.#, Yan L.#, Ji L., Chen Y., Zhao M., Dong X. A ternary classification using machine learning methods of distinct estrogen receptor activities within a large collection of environmental chemicals [J]. Science of the Total Environment, 2017, 580: 1268-75.（共一）
9. Tian M.#, Xia P.#, Yan L. #, Gou X., Yu H., Human functional genomics reveals toxicological mechanism underlying genotoxicants-induced inflammatory responses under low doses exposure [J]. Chemosphere, 2023, 314: 137658.（共一）
