Name: Qian Xu
Title: Associate Professor
Email: xiaoqian7666@163.com
Education Background
09.2014--11.2015: Joint PhD Program, School of Pharmacy and Molecular Biosciences, University of Pittsburgh, USA
09. 2013--06. 2016: PhD in Pharmaceutics, School of Pharmacy, Southern Medical University
09. 2010--07. 2013: Master in Pharmaceutics, School of Pharmacy, Southern Medical University
09. 2006--06. 2010: Bachelor in Pharmacy, Jiangxi University of Traditional Chinese Medicine
Work Experience
08.2024--Present: Deputy Dean, School of Life Sciences, Nanyang Normal University
01.2022--Present: Associate Professor, Modern Biotechnology Research Institute, School of Life Sciences, Nanyang Normal University
05.2021--07.2024: Chief of Organizational Section, Organization Department, CPC Committee of Nanyang Normal University
09.2021--09.2022: Director of Research and Production Department (on a temporary assignment), Zhengzhou Yuanchuang Genetic Technology Co., Ltd.
09.2018--09.2019: On a temporary assignment at Neurology Department, Nanyang Central Hospital
06.2016--12.2021: Lecturer, School of Life Sciences, Nanyang Normal University
Teaching Responsibilities
Undergraduate Courses: Biochemistry, General Chemistry, Cell Biology, etc.
Research Interests
AI Big Data Application and Pharmacogenomics;
Intelligent Diagnosis and Treatment, Drug Innovation
Research Achievements
(I) Research Projects
1) National Natural Science Foundation for Young Scholars: Function and Mechanism of lncRNA-C2dat2 in Promoting Neuronal Apoptosis via Phosphorylation and Activation of the C2MK2/P38 Signaling Pathway after Cerebral Ischemia-Reperfusion. Project No. 81701185, 2018/01-2020/12. Role: Principal Investigator, Completed.
2) Henan Provincial Key R&D Program Sub-project: Promoting Vascular Neogenesis after Ischemic Moyamoya Disease Surgery Based on the Theory of Qi and Blood. 2024/01-2026/12. Role: Principal Investigator, Ongoing.
3) Henan Provincial Airport Economic Zone Innovative Leading Team Project Sub-project: Research and Application of Autologous Somatic Cells Combined with Acupoint Injection. Approval No. [2022]58, 2022/07-2024/06. Role: Principal Investigator, Ongoing.
4) Henan Provincial Science and Technology Public Relations Project: Individualized Diagnosis and Clinical Decision-Making System Research Based on the Risk Model of Atrial Fibrillation and Cerebral Embolism. Project No. 232102310042, 2023/01-2024/12. Role: Principal Investigator, Ongoing.
5) Henan Provincial Key Research Project of Colleges and Universities: Development of Individualized Kits for Lung Adenocarcinoma Based on PCR Chips. Project No. 22A320039, 2021/09-2023/09. Role: Principal Investigator, Ongoing.
6) Nanyang Normal University National Fund Cultivation Project: Screening and Clinical Application of Risk Genes for Cardioembolic Stroke. Project No. 2023PY008, Jan. 2023 - Dec. 2024. Host, Ongoing.
7) Key Research Project of Henan Higher Education Institutions: Study on the Function and Mechanism of lncRNA-C2dat Activating C2MK2/P38 Signaling Pathway to Regulate Neuronal Autophagy and Apoptosis after Cerebral Ischemia; Project Number 18A320003, from January 2018 to December 2019, Principal Investigator, Completed, funded with 50,000 RMB.
8) Horizontal Project: Application of Biomarkers Screened by PCR Chip in Personalized Diagnosis and Treatment of Cardioembolic Stroke; Project Number 202102310406, from January 2021 to December 2022, Principal Investigator, Completed, funded with 89,000 RMB.
9) Horizontal Project: Study on the Mechanism of Zhengtian Pill in Treating Migraine through Regulation of P2X3 Receptor/5-HT7 Receptor, Nanyang Normal University, from July 2019 to August 2021, Nanyang Normal University, Principal Investigator, Completed, funded with 100,000 RMB.
(II) Publications
1) Shoudu Zhang, Yugang Guo, Yuanzheng Hu, Xiaofang Gao, Fanghui Bai, Qian Ding, Kaiqi Hou, Hui Zhao, Zhongyu Qu, Qian Xu. The role of APOBEC3C in modulating the tumor microenvironment and stemness properties of glioma: evidence from pancancer analysis.Front Immunol. 2023 Sep 21:14:1242972.(IF=8.3, JCR Q1)
2) Qian Ding#, Juan Xing #, Fanghui Bai ,Wei Shao ,Kaiqi Hou, Shoudu Zhang ,Yuanzheng Hu , Baochao Zhang *, Hui Zhao *,and Qian Xu* C1QC, VSIG4, and CFD as Potential Peripheral Blood Biomarkers in Atrial Fibrillation-Related Cardioembolic Stroke. Oxidative Medicine and Cellular Longevity, 2023 Jan 5;2023:5199810. (IF=7.3, EI, JCR Q1)
3) Wei Shao# ，Hui Zhao#, Shoudu Zhang, Qian Ding,Yugang Guo, Kaiqi Hou, Yunchao Kan,Fan Deng* and Qian Xu*.A pan-cancer landscape of IGF2BPs and their association with prognosis, stemness and tumor immune microenvironment ，Front Oncol 2023 Jan 4;12:1049183. eCollection 2022. (IF=4.7, JCR Q2)
4) Jiawei Zhou#, Hui Zhao#, Yugang Guo, Kaiqi Hou, Qian Ding,Wei Shao,Qian Xu*.Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma. Frontiers in Bioscience-Landmark. 2023 Jan 13;28(1):9.(IF=3. 1, JCR Q2)
5) Wei Shao#, Qian Ding, Yugang Guo, Juan Xing, Zheng Huo, Zhan Wang, Qian Xu* and Yue Guo*A Pan-Cancer Landscape of HOX-Related lncRNAs and Their Association With Prognosis and Tumor Microenvironment. Front Mol Biosci. 2021; 8: 767856 (IF=5.0,JCR Q2)
6) Yugang Guo#, Zhongyu Qu, Dandan Li , Fanghui Bai , Juan Xing , Qian Ding, Jiawei Zhou , Lunguang Yao,and Qian Xu*. Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma. Cell Death Discov. 2021 Jul 26;7(1):190. (IF= 7, JCR Q2 )
7) Jiawei Zhou#, Yugang Guo, Zheng Huo, Jintao Fang, Guohui Ma, Qinghui Han, Mengzhen Wang, Qian Xu*.Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma. Aging-us, 2021 Jan 20;13(3):4503-4521. (IF=5.2, JCR Q2)
8) Qian Xu# *, Guohui Ma#, Dandan Li, Fanghui Bai, Jintao Fang, Gui Zhang, Yuxin Xing, Jiawei Zhou, Yugang Guo, and Yunchao Kan*. lncRNA C2dat2 facilitates apoptosis and autophagy via miR-30d-5p/DDIT4/mTOR axis in cerebral ischemia–reperfusion injury, Aging-us, 2021 Apr4;13(8):11315-11335 (IF=5.2, JCR Q2)
9) Qian Xu#, Fan Deng, Zhe Xing, Zhuomin Wu, Bohong Cen, Shuping Xu, Rachel Nepomuceno, Dandan Sun, Q. Jane Wang*, and Aimin Ji*. Long Non-Coding RNA C2dat1 Regulates CaMKIIδ Expression to Promote Neuronal Survival Through the NF-κB Signaling Pathway. Cell Death & Disease.2016 Mar; 7(3): e2173. (IF=9, JCR Q1）
10) Qian Xu#, Fan Deng, Yixin Qin, Zhenlong Zhao ，Zhuomin Wu, Aimin Ji*, and Q. Jane Wang*. Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis. Cell Death & Disease, 2016, 7(6) , e2254 (IF=9,JCR Q1）
(III) Granted Patents
1) Xu Qian, Zhao Ke, Kan Yunchao, Yao Lunguang, Li Aoqi, Li Xinru; Detection of miRNA Combination for Lung Cancer Brain Metastasis and Kit Containing the Same, December 28, 2021, ZL201810647479.6 (Granted)
2) Xu Qian, Guo Yugang, Li Dandan, Wang Mengzhen, Yao Lunguang, Kan Yunchao; A Biomarker for Predicting Prognosis of Colon Cancer and its Prognosis, September 22, 2023, ZL202010658277.9 (Granted)
Research and Teaching Honors
(I) Personal Honors and Awards: 6 items
1) Awarded as "Wolong Scholar" of Nanyang Normal University (2018)
2) Third Prize of Henan Provincial Medical Science and Technology Award (January 2021)
3) Second Prize of Excellent Scientific Paper Award from the Henan Provincial Department of Education (June 2022)
4) First Prize of Excellent Scientific Paper Award from the Henan Provincial Department of Education (June 2024)
5) Outstanding Graduate Supervisor of Nanyang Normal University (2023)
6) Excellent Communist Party Member of Nanyang Normal University (2018)
(I) Honors Guided by the Supervisor: 5 items
1) Excellent Undergraduate Graduation Thesis of Nanyang Normal University (2024)
2) Excellent Graduate Graduation Thesis of Nanyang Normal University (2023, 2023)
3) Outstanding Paper Award at the China Tumor Marker Conference (guided graduate student in 2023)
4) Two Graduate Innovation Funds of Nanyang Normal University (2021, 2022)
5) Second Prize in the Henan Provincial "Internet +" College Students' Innovation and Entrepreneurship Competition, as a Mentoring Teacher (December 2018)
Student Mentoring
Since joining the faculty, I have guided 15 undergraduate students majoring in bioscience, agriculture, and pharmaceutical engineering to be admitted into prestigious universities for graduate studies in pharmacy/biology. Additionally, I have supervised one graduate student to successfully enroll in a Ph.D. program in biology at a 211 university's medical school. Furthermore, I have mentored undergraduate students in pharmaceutical engineering to publish 2 SCI papers as first authors.