姓名:唐存多
性别:男
职称:副教授
电子邮箱:tcd530@126.com
人才称号:河南省高校科技创新人才,河南省青年科学家,河南省青年人才
托举工程人选
一、学习经历
2008.09-2014.01,江南大学,发酵工程,博士
2004.09-2008.06,苏州科技大学,生物技术,学士
二、工作经历
2024.05-,南阳师范学院生命科学学院,副教授
2020.10-2024.04,南阳师范学院生命科学与农业工程学院,副教授
2015.09-2020.09,南阳师范学院农业工程学院,讲师、副教授
2014.02-2015.08,南阳师范学院生命科学与技术学院,讲师
三、教学工作
主讲课程
本科生:《基因工程》《蛋白质技术》《酶工程》《蛋白质组学》《发酵工艺学》等课程的教学工作。
四、科学研究方向
人工智能辅助蛋白质的理性设计与改造、功能性食品及药物中间体的生物合成、二氧化碳的人工捕获封存与高值利用。
五、科研成果
(一)科研项目
1.国家自然科学基金委员会,青年项目,31900916,D-扁桃酸脱氢酶底物选择性的分子机制及其理性改造,2020-01至2022-12,25万元,已结题,主持。
2.河南省教育厅,河南省高校科技创新人才,21HASTIT041,生物催化与生物合成,2021-01至2023-12,30万元,已结题,主持。
3.河南省科学技术协会,河南省青年人才托举工程项目,2021HYTP036,高产γ-氨基丁酸微生物细胞工厂的设计与构建,2021-01至2022-12,已结题,主持。
4.河南省科技厅,河南省青年科学家项目,225200810076,基于计算机辅助的底物口袋工程对甲酸脱氢酶催化活性的分子改造,2023-01至2024-12,在研,主持。
(二)论文著作
1.ShiHongling,FuMuran,YuanShuwei,LuYunfeng,YangZhuan,YueChao,YaoLunguang*,XueChuang*,TangCunduo*.EngineeredEscherichiacoliWholeCell-MediatedElectro-BiocatalysisforCarbonDioxidetoFormicAcidConversion.ACSSustainableChem.Eng.2024,12(14):5544-5554.(中科院JCR1区)
2.HuDie,JiaXue-Wei,LuJia-Lan,LuZhi-Yi,TangCunduo*,XueFeng,HuangChao,RenQing-Gong,HeYu-Cai*.ChemoenzymaticAsymmetricSynthesisofChiralTriazoleFungicide(R)-TebuconazoleinHighOpticalPurityMediatedbyanEpoxideHydrolasefromRhodotorulapaludigensis.JAgricFoodChem2024,72(18):10428-10438.(中科院JCR1区)
3.ZhangXiang,ZhangXichuan,ShiHongling,ZhangHuimin,ZhangJianhui,YueChao,LiDandan*,YaoLunguang*,TangCunduo*.CombiningFlexibleRegionDesignandAutomaticDesigntoEnhancetheThermalStabilityandCatalyticEfficiencyofLeucineDehydrogenase.JAgricFoodChem2024,72(24):13801-13811.(中科院JCR1区)
4.TangCunduo*,LiXiang,ShiHong-Ling,JiaYuan-Yuan,DongZi-Xing,JiaoZhu-Jin,WangLin-Feng,XuJian-He,YaoLun-Guang*,KanYun-Chao*.Efficientexpressionofnovelglutamatedecarboxylasesandhighlevelproductionofgamma-aminobutyricacidcatalyzedbyengineeredEscherichiacoli.IntJBiolMacromol2020,160:372-379.(中科院JCR1区)
5.TangCunduo*,DingPeng-Ju,ShiHong-Ling,JiaYuan-Yuan,ZhouMao-Zhi,YuHui-Lei,XuJian-He,YaoLun-Guang*,KanYun-Chao*.One-PotSynthesisofPhenylglyoxylicAcidfromRacemicMandelicAcidsviaCascadeBiocatalysis.JAgricFoodChem2019,67(10):2946-2953.(中科院JCR1区)
6.TangCun-Duo*,ShiHong-Ling,XuJian-He,JiaoZhu-Jin,LiuFeng,DingPeng-Ju,ShiHong-Fei,YaoLun-Guang,KanYun-Chao.BiosynthesisofPhenylglyoxylicAcidbyLhDMDH,aNovelD-MandelateDehydrogenasewithHighCatalyticActivity.JAgricFoodChem2018,66(11):2805-2811.(中科院JCR1区)
7.LiuXin-Xin,WangYao,ZhangJian-Hui,LuYun-Feng,DongZi-Xing,YueChao,HuangXian-Qing,ZhangSi-Pu,LiDan-Dan,YaoLun-Guang,TangCun-Duo*.EngineeringEscherichiacoliforhigh-yielding2,5-DimethylpyrazinesynthesisfromL-Threoninebyreconstructingmetabolicpathwaysandenhancingcofactorsregeneration.BiotechnologyforBiofuelsandBioproducts2024,17(1):44.(中科院JCR2区)
8.ZhangXiang,ZhangXi-Chuan,ShiHong-Ling,ZhangHui-Min,ZhangJian-Hui,KanYun-Chao,LiDan-Dan,YaoLun-Guang,TangCun-Duo*.EnhancingthethermostabilityoftheleucinedehydrogenasefromPlanifilumfimeticolathroughrationaldesignoftheflexibleregion.MolecularCatalysis2024,559:114048.(中科院JCR2区)
9.LiuXin-Xin,XiXiao-Qi,ShenTai-Song,ShiHong-Ling,ZhangYing-Jun,KanYun-Chao,YaoLun-Guang,TangCun-Duo*.Enhancingbiosynthesisefficiencyof2,5-dimethylpyrazinebyoverexpressing-threoninedehydrogenaseandNADHoxidaseinEscherichiacoli.MolecularCatalysis2023,550:113550.(中科院JCR2区)
10.YuanShu-Wei,FuMu-Ran,XianYi-Meng,ShiHong-Ling,ChunChang,YaoLun-Guang,TangCun-Duo*,ChenChang-Po.Efficientheterologousexpressionofformatedehydrogenaseandpreliminarydeterminationofthepotentialforconversionofcarbondioxidetoformate.MolecularCatalysis2023,548:113455.(中科院JCR2区)
11.TangCun-Duo*,ZhangXiang,ShiHong-Ling,LiuXin-Xin,WangHong-Yan,LuYun-Feng,ZhangSi-Pu,KanYun-Chao,YaoLun-Guang.ImprovingcatalyticactivityofLactobacillusharbinensis-mandelatedehydrogenasetoward-o-chloromandelicacidbylaboratoryevolution.MolecularCatalysis2022,531:112700.(中科院JCR2区)
12.TangCun-Duo,ZhangZhen-Hua,ShiHong-Ling,XieYu-Li,YangTian-Tian,LuYun-Feng,ZhangSi-Pu,BaiFang-Hui,KanYun-Chao,YaoLun-Guang.DirectedevolutionofformatedehydrogenaseanditsapplicationinthebiosynthesisofL-phenylglycinefromphenylglyoxylicacid.MolecularCatalysis2021,513:111666.(中科院JCR2区)
(三)授权专利
1.唐存多,史红玲,阚云超,姚伦广,和子涵,焦铸锦,史鸿飞.一种D-扁桃酸脱氢酶、基因、基因工程菌及其应用,2019-9-24,中国发明专利,ZL201710969932.0。
2.唐存多,姚伦广,阚云超,史红玲,董自星,史鸿飞,焦铸锦.一种编码谷氨酸脱羧酶LsGAD的基因、重组工程菌及康普茶发酵菌剂,2023-3-24,中国发明专利,ZL201911234346.7。
(四)科研及教学奖励
1.唐存多(1/5);BiosynthesisofPhenylglyoxylicAcidbyLhDMDH,aNovelD-MandelateDehydrogenasewithHighCatalyticActivity,河南省教育厅,河南省教育厅优秀学术论文奖,一等奖,2021。
2.唐存多(1/2);One-PotSynthesisofPhenylglyoxylicAcidfromRacemicMandelicAcidsviaCascadeBiocatalysis,河南省教育厅,河南省教育厅优秀学术论文奖,一等奖,2022。
3.唐存多(1/9);BiosynthesisofPhenylglyoxylicAcidbyLhDMDH,aNovelD-MandelateDehydrogenasewithHighCatalyticActivity,河南省人社厅/河南省科学技术协会,河南省自然科学学术奖,一等奖,2021。