李丹丹

作者:

名:李丹丹

别:女

称:教授

电子邮箱:lidannytc@126.com

人才称号:中国科协青年人才托举工程项目人选,河南省优青,河南省教育厅学术技术带头人,南阳市拔尖人才,南阳市最美青年科技工作者,卧龙特聘教授

一、 学习经历

2007.09-2010.07,南京农业大学,农业昆虫与害虫防治,博士

2004.09-2007.07,河南师范大学,植物学,硕士  

2000.09-2004.07,南阳师范学院,生物科学,学士  


二、工作经历

2010.08-2014.02  南阳师范学院生命科学与技术学院    讲师

2014.3-2020.03   南阳师范学院农业工程学院    副教授

2020.04-至今    南阳师范学院生命科学学院    教授

2017.09.11-2018.09.05  美国加州大学圣地亚哥分校 访问学者

2020.10-至今 南阳师范学院现代生物技术研究院院长(兼生命科学学院副院长)

三、教学工作

主讲课程:本科生《细胞生物学》、《蛋白质组学》、《生物信息学》

研究生:《高级细胞生物学》

四、研究方向

新型RNA生物农药研发、鳞翅目昆虫变态发育及生殖调控机制、非编码RNA组学研究。

五、科研成果

(一)科研项目

1. 国家自然科学基金面上项目:核仁小RNA调控果蝇性别决定及关键基因可变剪接机制的研究3197048058万,主持

2. 国家自然科学基金青年基金:家蚕非编码RNA Bm-15Notch信号通路及发育过程中的功能研究,3110093822万,主持

3. 中国科协青年人才托举工程项目:家蚕长链非编码RNA的功能解析,YESS2015002645万,主持

4. 河南省自然科学基金-优秀青年基金:核仁小RNA在家蚕mRNA加工及生殖发育过程的调控机制研究,21230041006325万,主持

5. 河南省重点研发专项子课题:基于核酸类新农药的农作物病虫害绿色防控关键技术研发与集成示范,23111111100020万,主持

6. 河南省科技厅项目:宿主诱导的RNA沉默对草地贪夜蛾杀虫效果研究,HNGD202104913万,主持

7 河南省科技厅项目:家蚕丝腺长链非编码RNA的系统挖掘及功能初探,1623004101335万,主持

8. 南阳师范学院校级青年骨干教师培养计划:蚜虫翅两型性分化的激素与非编码RNA调控研究,nynuxjqg-2019-03 ,主持

9. 国家自然科学基金面上项目:调控家蚕发育非编码RNAnon-coding RNAncRNA)的功能解析,31172158,参与

10. 国家自然科学基金面上项目:家蚕神经系统piRNA的系统挖掘及功能解析, 31470114,参与


(二)论文著作

1. Zhiyan Cai, Xuhui Zhao, Yuxin Qian, Kun Zhang, Yuxin Qian, Yunchao Kan, Yuqing Wang, Camilo Ayra-Pardo*, Dandan Li*.Transcriptomic and metatranscriptomic analyzes provide new insights into the response of the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) to acetamiprid. Insects, 2024, 15, 274.

2. Bing Zhang, Camilo Ayra-Pardo, Xiao Liu, Meiting Song, Dandan Li, Yunchao Kan. siRNA-Mediated BmAurora B Depletion Impedes the Formation of Holocentric Square Spindles in Silkworm Metaphase BmN4 Cells. Insects, 2024, 15, 72.

3. Yuxin Qian, Shigang Guo, Xuhui Zhao, Zhongwei Li, Reng Qiu, Yunchao Kan*, Dandan Li*. Role of small nucleolar RNAs in alternative splicing of the doublesex gene in the silkworm, Bombyx mori. Archives of Insect Biochemistry and Physiology. 2024, 116: e22117.

4. Qunxia Huang, Chunyue Huo, Yuxin Qian, Chenyue Zhao, Zhiyan Cai, Kun Zhang, Xuhui Zhao, Shigang Guo, Yunchao Kan, Dandan Li*, m6A writer gene fl(2)d regulates the metamorphosis of silkworm Bombyx mori, Journal of Asia-Pacific Entomology, 2023, 26(4): 102126.

5. Chenyue Zhao, Qunxia Huang, Yuxin Qian, Xuhui Zhao, Shigang Guo, Yunchao Kan*, Dandan Li*. The hypothetical cuticular protein, CPH19, is involved in cuticle formation during molt of silkworm Bombyx mori. 2023, Journal of Asia-Pacific Entomology. 2023, 26(3) : 102111.

6. Yi Wang, Yu Fu, Hao Cheng, Chenyue Zhao, Qunxia Huang, Meiling Chang, Wujie Qiu, Yawen Shen, Dandan Li*. lncR26319/miR-2834/EndophilinA axis regulates oogenesis of the silkworm, Bombyx mori. Insect Science, 2022, 30(1):65-80.

7. Meiling Chang, Hao Cheng, Zhiyan Cai, Yuxin Qian, Kun Zhang, Linlin Yang, Na Ma*, Dandan Li*. miR-92a-1-p5 Modulated Expression of the flightin Gene Regulates Flight Muscle Formation and Wing Extension in the Pea Aphid, Acyrthosiphon pisum (Hemiptera: Aphidoidea). Journal of Insect Science, 2022, 22(3): 14; 1–8.

8. Yu Fu,Yi Wang, Qunxia Huang, Chenyue Zhao, Xinmei Li, Yunchao Kan*, Dandan Li*. Long Noncoding RNA lncR17454 Regulates Metamorphosis of Silkworm Through let-7 miRNA Cluster. Journal of Insect Science, 2022, 22(3): 12; 1–8.

9. Hao Cheng, Yanyan Wang, Meiling Chang, Kun Zhang, Zhiyan Cai, Yuxin Qian, Dandan Li*. Sperm maturation screening and the effect of ecdysone on sperm development of silkworm Bombyx mori. Journal of Asia-Pacific Entomology. 2022, 25:101916.

10. Linlin Yang, Yanyan Sun, Meiling Chang, Yun Zhang, Huili Qiao, Siliang Huang, Yunchao Kan, Lunguang Yao, Dandan Li*, Camilo Ayra-Pardo*. RNA Interference-Mediated Knockdown of Bombyx mori Haemocyte-Specific Cathepsin L (Cat L)-Like Cysteine Protease Gene Increases Bacillus thuringiensis kurstaki Toxicity and Reproduction in Insect Cadavers. Toxins, 2022, 14, 394.

11. Yanyan Sun, Linlin Yang, Lianet Rodríguez-Cabrera, Yushan Ding, Chaoliang Leng, Huili Qiao, Siliang Huang,Yunchao Kan, Lunguang Yao, Denis J. Wright, Dandan Li*, Camilo Ayra-Pardo*. Tandem Mass Tag-Based Quantitative Proteomics and Virulence Phenotype of Hemolymph-Treated Bacillus thuringiensis kurstak Cells Reveal New Insights on Bacterial Pathogenesis in Insects, Microbiology Spectrum. 2021, e00604-21.

12. Chunyue Huo, Meiling Chang, Hao Cheng, Tiantian Ma, Yu Fu, Yi Wang, Yanyan Wang, Yunchao Kan*, Dandan Li*. Small nucleolar RNA of silkworm can translocate from the nucleolus to the cytoplasm under abiotic stress. Cell Biology International. 2021, DOI: 10.1002/cbin.11555.

13. Cui B, Fan X, Zhou D, Lifeng He, Yiyun Li, Dandan Li*, Hui Lin*. CSF1R methylation is a key regulatory mechanism of tumor‑associated macrophages in hepatocellular carcinoma. Oncology letters, 2020, 20: 1835-1845.

14. Bo Wu, Lei Huang, Wujie Qiu, Xiao Liu, Yawen Shen, Yiping Lu, Zonglin Yang, Xinmei Li, Bin Cui, Shidong Xu, Huili Qiao, Reng Qiu, Lunguang Yao, Yunchao Kan*, Dandan Li*. Small nucleolar RNA Sf-15 regulates proliferation and apoptosis of Spodoptera frugiperda Sf9 cells. BMC Molecular Biology, 2019, 20(1): 12.

15. Dandan Li, Huili Qiao, Wujie Qiu, Xin Xu, Tiemei Liu, Qianling Jiang, Renyi Liu, Zhujin Jiao, Kun Zhang, Lijun Bi, Runsheng Chen, Yunchao Kan*. Identification and functional characterization of intermediate-size non-coding RNAs in maize. 2018, BMC Genomics, 19:730.

16. Dandan Li, Zongcai Liu, Lei Gao, Lifang Wang, Meijuan Gao, Zhujin Jiao, Huili Qiao, Jianwei Yang, Min Chen, Lunguang Yao, Renyi Liu, Yunchao Kan*. Genome-Wide Identification and Characterization of microRNAs in Developing Grains of Zea mays L. Plos One. 2016, 11(4): e0153168.

17. Dandan Li, Zongcai Liu, Lei Huang, Qianling Jiang, Kun Zhang, Huili Qiao, Zhujin Jiao, Lunguang Yao, Renyi Liu*, Yunchao Kan*. The expression analysis of silk gland-enriched intermediate-size non-coding RNAs in silkworm Bombyx mori. Insect Science, 2014, 21(4): 429-438.

18. Dandan LiYanhong Wang, Kun Zhang, Zhujin Jiao, Xiaopeng Zhu, Geir Skogerboe, Xiangqian Guo, Viswanathan Chinnusamy, Lijun Bi, Yongping Huang, Shuanglin Dong*, Runsheng Chen*, Yunchao Kan*. Experimental RNomics and genomic comparative analysis reveal a large group of species-specific small non-message RNAs in the silkworm Bombyx mori. Nucleic Acids Research. 2011, 39 (9): 3792-3805.

19. 张琨,郭士刚,常美玲,余明玉,阚云超,李丹丹*.纳米递送系统介导的蚜虫四个编码基因 RNA 干涉条件筛选. 昆虫学报,2024, 4.

20. 马田田, 杨宗霖, 常美玲, 霍春月, 阚云超, 李丹丹*. 蚜虫翅发育相关miRNA对蜕皮激素的应答及对靶基因的调控. 昆虫学报,2021, 64(4): 9.

21. 霍春月,程浩,付裕,常美玲,王艺,阚云超,李丹丹*. 家蚕BmlncR2036调控P25基因启动子活性及参与中肠功能调控的初步研究. 昆虫学报,2021, 64(8): 11.

22. 邱妩洁,庞佳林,马田田,霍春月,杨宗霖,申雅文,李丹丹*. 鳞翅目核仁小RNA Sf-15在逆境胁迫下的表达分析,蚕业科学,201945(5): 769-772.

23. 杨宗霖, 王艺, 马田田, 霍春月, 刘晓, 阚云超, 李丹丹*.有翅和无翅豌豆蚜中翅型分化信号通路相关微小RNA及其靶基因的表达差异. 昆虫学报,2019, 62(11): 1260-1270.

24. 申雅文, 马田田, 霍春月, 杨宗霖, 路一平, 阚云超, 李丹丹*. 家蚕snoRNA Bm-15的细胞定位及与类Notch受体基因的互作关系. 昆虫学报,201962(8)895-900.

25. 路一平, 霍春月, 马田田, 杨宗霖, 申雅文, 阚云超, 李丹丹*. 利用体腔显微注射法实现非编码RNA在家蚕头部稳定过表达. 昆虫学报,201962(7)779-786.

26. 李新梅, 邱妩洁, 崔斌, 杨宗霖, 申雅文, 路一平, 阚云超, 李丹丹*。草地贪夜蛾Sf9细胞中snoRNA Bm-15反义寡核苷酸的定位及其对Bm-15的干涉效率。昆虫学报,201861(7)795-800.

27. 刘晓,邱妩洁,李新梅,阚云超,李丹丹*. 家蚕非编码RNA Bm-152功能初探. 信阳师范学院学报(自然科学版). 2018, 31(1): 40-45.

28. 王立方, 乔惠丽, 吴博, 张丹, 阚云超, 李丹丹*. 家蚕非编码RNA在神经系统中的表达分析. 昆虫学报, 2015, 58(8): 926-932.


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