李娜,女,1983年6月出生,博士,讲师。毕业于西北农林科技大学,预防兽医学博士。从事病毒与宿主相互作用以及非编码RNA对于基因调控等科研工作,已发表SCI论文10余篇。目前主要从事分子病毒学,畜禽传染病分子诊断,病毒样颗粒疫苗及生物制品研发等研究工作。
受教育经历
2003-2007年 西南大学蚕学与生物技术学院 学士
2007-2010年 西南大学家蚕基因组生物学国家重点实验室 硕士
2012-2016年 西北农林科技大学动物医学院 博士
研究工作经历
2017.03-至今 南阳师范学院 农业工程学院 讲师
代表性论文
1. Li N., Du T.F. , Yan Y.H. , Zhang A.K., Gao J.M., Hou G.P., Xiao S.Q.*, and Zhou E.M*. MicroRNA let-7f-5p Inhibits Porcine Reproductive and Respiratory Syndrome Virus by Targeting MYH9. Scientific reports, 2016, 6:34332.
2. Li N., Yan Y.H., Zhang A.K., Gao J.M., Zhang C., Wang X., Hou G.P., Zhang G.P., Jia J.B., Zhou E.M. *, and Xiao S.Q*. MicroRNA-like viral small RNA from porcine reproductive and respiratory syndrome virus negatively regulates viral replication by targeting the viral nonstructural protein2. Oncotarget, 2016, 7(50):82902-82920.
3. Zhang, A., Duan, H., Li, N., Zhao, L., Pu, F., Huang, B., Wu, C., Nan, Y., Du, T., Mu, Y., Zhao, Q., Sun, Y., Zhang, G., Hiscox, J. A., Zhou, E. M., and Xiao, S. (2017) Heme oxygenase-1 metabolite biliverdin, not iron, inhibits porcine reproductive and respiratory syndrome virus replication. Free radical biology & medicine 102, 149-161
4. Zhang, A., Zhao, L., Li, N., Duan, H., Liu, H., Pu, F., Zhang, G., Zhou, E. M., and Xiao, S. (2016) Carbon Monoxide Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by the cGMP/PKG and NF-kappaB Signaling Pathway. Journal of virology
5. Xiao, S., Du, T., Wang, X., Ni, H., Yan, Y., Li, N., Zhang, C., Zhang, A., Gao, J., Liu, H., Pu, F., Zhang, G., and Zhou, E. M. (2016) MiR-22 promotes porcine reproductive and respiratory syndrome virus replication by targeting the host factor HO-1. Vet Microbiol 192, 226-230
6. Xiao, S., Wang, X., Ni, H., Li, N., Zhang, A., Liu, H., Pu, F., Xu, L., Gao, J., Zhao, Q., Mu, Y., Wang, C., Sun, Y., Du, T., Xu, X., Zhang, G., Hiscox, J. A., Goodfellow, I. G., and Zhou, E. M. (2015) MicroRNA miR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression. Journal of virology 89, 4494-4503
7. Zhang, C., Pu, F., Zhang, A., Xu, L., Li, N., Yan, Y., Gao, J., Liu, H., Zhang, G., Goodfellow, I. G., Zhou, E. M., and Xiao, S. (2015) Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro. Scientific reports 5, 15575
8. Gao, J., Ji, P., Zhang, M., Wang, X., Li, N., Wang, C., Xiao, S., Mu, Y., Zhao, Q., Du, T., Sun, Y., Hiscox, J. A., Zhang, G., and Zhou, E. M. (2014) GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity. Vet Microbiol 174, 409-418
9. Xiao, S., Zhang, A., Zhang, C., Ni, H., Gao, J., Wang, C., Zhao, Q., Wang, X., Wang, X., Ma, C., Liu, H., Li, N., Mu, Y., Sun, Y., Zhang, G., Hiscox, J. A., Hsu, W. H., and Zhou, E. M. (2014) Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro. Antiviral research 110, 60-69
10. Zhang, J., He, Q., Zhang, C. D., Chen, X. Y., Chen, X. M., Dong, Z. Q., Li, N., Kuang, X. X., Cao, M. Y., Lu, C., and Pan, M. H. (2014) Inhibition of BmNPV replication in silkworm cells using inducible and regulated artificial microRNA precursors targeting the essential viral gene lef-11. Antiviral research 104, 143-152
11. 李娜,肖书奇,张冲,张昂克,侯高鹏,周恩民*.利用TALEN及CRISPR-Cas9系统对于PRRSV受体NMHC II-A的基因编辑及功能研究. 中国畜牧兽医学会畜牧兽医生物技术学分会暨中国免疫学会兽医免疫分会第十次学术研讨会. 367,2014.
12. 李娜,肖书奇,闫云欢,张冲,张昂克,周恩民*.猪繁殖与呼吸综合征病毒类似microRNA的病毒小RNA的预测验证及功能分析. 中国畜牧兽医学会动物传染病学分会第十六次学术研讨会. 69, 2015.